diff --git a/internal/devserver/server.go b/internal/devserver/server.go
index 09d47854f..dcd09031f 100644
--- a/internal/devserver/server.go
+++ b/internal/devserver/server.go
@@ -40,6 +40,7 @@ import (
 	uiserveroptions "github.com/temporalio/ui-server/v2/server/server_options"
 	"go.temporal.io/api/enums/v1"
 	"go.temporal.io/server/chasm/lib/activity"
+	"go.temporal.io/server/chasm/lib/nexusoperation"
 	"go.temporal.io/server/common/authorization"
 	"go.temporal.io/server/common/cluster"
 	"go.temporal.io/server/common/config"
@@ -250,6 +251,9 @@ func (s *StartOptions) buildServerOptions() ([]temporal.ServerOption, *slog.Leve
 	dynConf[activity.EnableStandaloneActivityOperatorCommands.Key()] = true
 	dynConf[dynamicconfig.FrontendEnableBatchOperationsForStandaloneActivities.Key()] = true
 
+	// Enable SANO; this can be removed when SANO is on by default.
+	dynConf[nexusoperation.Enabled.Key()] = true
+
 	// Dynamic config if set
 	for k, v := range s.DynamicConfigValues {
 		dynConf[dynamicconfig.MakeKey(k)] = v
diff --git a/internal/temporalcli/commands.gen.go b/internal/temporalcli/commands.gen.go
index a48152714..3f625ab05 100644
--- a/internal/temporalcli/commands.gen.go
+++ b/internal/temporalcli/commands.gen.go
@@ -1523,6 +1523,7 @@ func NewTemporalNexusOperationCommand(cctx *CommandContext, parent *TemporalNexu
 	s.Command.Args = cobra.NoArgs
 	s.Command.AddCommand(&NewTemporalNexusOperationCancelCommand(cctx, &s).Command)
 	s.Command.AddCommand(&NewTemporalNexusOperationCountCommand(cctx, &s).Command)
+	s.Command.AddCommand(&NewTemporalNexusOperationDeleteCommand(cctx, &s).Command)
 	s.Command.AddCommand(&NewTemporalNexusOperationDescribeCommand(cctx, &s).Command)
 	s.Command.AddCommand(&NewTemporalNexusOperationExecuteCommand(cctx, &s).Command)
 	s.Command.AddCommand(&NewTemporalNexusOperationListCommand(cctx, &s).Command)
@@ -1588,6 +1589,35 @@ func NewTemporalNexusOperationCountCommand(cctx *CommandContext, parent *Tempora
 	return &s
 }
 
+type TemporalNexusOperationDeleteCommand struct {
+	Parent  *TemporalNexusOperationCommand
+	Command cobra.Command
+	NexusOperationReferenceOptions
+	Yes bool
+}
+
+func NewTemporalNexusOperationDeleteCommand(cctx *CommandContext, parent *TemporalNexusOperationCommand) *TemporalNexusOperationDeleteCommand {
+	var s TemporalNexusOperationDeleteCommand
+	s.Parent = parent
+	s.Command.DisableFlagsInUseLine = true
+	s.Command.Use = "delete [flags]"
+	s.Command.Short = "Remove a Nexus Operation Execution (Experimental)"
+	if hasHighlighting {
+		s.Command.Long = "Delete a Nexus Operation Execution and its history. The request runs\nasynchronously. If the Operation is running, the Service terminates it\nbefore deletion. Without a Run ID, the latest run is deleted.\n\n\x1b[1mtemporal nexus operation delete \\\n    --operation-id YourOperationId \\\n    --yes\x1b[0m\n\nUse \"--run-id\" to delete a specific run. Confirmation is required unless\n\"--yes\" is passed."
+	} else {
+		s.Command.Long = "Delete a Nexus Operation Execution and its history. The request runs\nasynchronously. If the Operation is running, the Service terminates it\nbefore deletion. Without a Run ID, the latest run is deleted.\n\n```\ntemporal nexus operation delete \\\n    --operation-id YourOperationId \\\n    --yes\n```\n\nUse \"--run-id\" to delete a specific run. Confirmation is required unless\n\"--yes\" is passed."
+	}
+	s.Command.Args = cobra.NoArgs
+	s.Command.Flags().BoolVarP(&s.Yes, "yes", "y", false, "Don't prompt to confirm deletion.")
+	s.NexusOperationReferenceOptions.BuildFlags(s.Command.Flags())
+	s.Command.Run = func(c *cobra.Command, args []string) {
+		if err := s.run(cctx, args); err != nil {
+			cctx.Options.Fail(err)
+		}
+	}
+	return &s
+}
+
 type TemporalNexusOperationDescribeCommand struct {
 	Parent  *TemporalNexusOperationCommand
 	Command cobra.Command
diff --git a/internal/temporalcli/commands.nexus_operation.go b/internal/temporalcli/commands.nexus_operation.go
index b289e4456..c97a39703 100644
--- a/internal/temporalcli/commands.nexus_operation.go
+++ b/internal/temporalcli/commands.nexus_operation.go
@@ -18,6 +18,8 @@ import (
 	"go.temporal.io/sdk/converter"
 )
 
+const nexusOperationDeleteWarning = "WARNING: Deleting Nexus Operation Executions in a global Namespace removes them from all replicas. Requests sent to a passive cluster are forwarded to the active cluster by default; to target the passive cluster directly, specify `--grpc-meta xdc-redirection=false`."
+
 func (c *TemporalNexusOperationStartCommand) run(cctx *CommandContext, args []string) error {
 	cl, err := dialClient(cctx, &c.Parent.Parent.ClientOptions)
 	if err != nil {
@@ -352,6 +354,59 @@ func (c *TemporalNexusOperationTerminateCommand) run(cctx *CommandContext, args
 	return nil
 }
 
+func (c *TemporalNexusOperationDeleteCommand) run(cctx *CommandContext, _ []string) error {
+	cl, err := dialClient(cctx, &c.Parent.Parent.ClientOptions)
+	if err != nil {
+		return err
+	}
+	defer cl.Close()
+
+	// Only warn when the namespace is global, or can't get the namespace info
+	nsResp, nsErr := cl.WorkflowService().DescribeNamespace(cctx, &workflowservice.DescribeNamespaceRequest{
+		Namespace: c.Parent.Parent.Namespace,
+	})
+	if nsErr != nil || nsResp.GetIsGlobalNamespace() {
+		fmt.Fprintln(cctx.Options.Stderr, nexusOperationDeleteWarning)
+	}
+
+	yes, err := cctx.promptYes(nexusOperationDeleteConfirmationMessage(c.OperationId, c.RunId), c.Yes)
+	if err != nil {
+		return err
+	} else if !yes {
+		return fmt.Errorf("user denied confirmation")
+	}
+
+	_, err = cl.WorkflowService().DeleteNexusOperationExecution(cctx, &workflowservice.DeleteNexusOperationExecutionRequest{
+		Namespace:   c.Parent.Parent.Namespace,
+		OperationId: c.OperationId,
+		RunId:       c.RunId,
+	})
+	if err != nil {
+		return fmt.Errorf("failed to delete nexus operation: %w", err)
+	}
+	if cctx.JSONOutput {
+		return cctx.Printer.PrintStructured(struct {
+			OperationId string `json:"operationId"`
+			RunId       string `json:"runId,omitempty"`
+			Status      string `json:"status"`
+		}{
+			OperationId: c.OperationId,
+			RunId:       c.RunId,
+			Status:      "DELETE_REQUESTED",
+		}, printer.StructuredOptions{})
+	}
+	cctx.Printer.Println("Nexus Operation deletion requested")
+	return nil
+}
+
+func nexusOperationDeleteConfirmationMessage(operationID, runID string) string {
+	action := fmt.Sprintf("Delete Nexus Operation %q", operationID)
+	if runID != "" {
+		action += fmt.Sprintf(" with Run ID %q", runID)
+	}
+	return fmt.Sprintf("%s? y/N", action)
+}
+
 func (c *TemporalNexusOperationListCommand) run(cctx *CommandContext, _ []string) error {
 	cl, err := dialClient(cctx, &c.Parent.Parent.ClientOptions)
 	if err != nil {
diff --git a/internal/temporalcli/commands.nexus_operation_test.go b/internal/temporalcli/commands.nexus_operation_test.go
index 0418c22f4..71fc7e2db 100644
--- a/internal/temporalcli/commands.nexus_operation_test.go
+++ b/internal/temporalcli/commands.nexus_operation_test.go
@@ -3,6 +3,7 @@ package temporalcli_test
 import (
 	"context"
 	"encoding/json"
+	"errors"
 	"fmt"
 	"strings"
 	"testing"
@@ -13,6 +14,7 @@ import (
 	"github.com/stretchr/testify/require"
 	nexuspb "go.temporal.io/api/nexus/v1"
 	"go.temporal.io/api/operatorservice/v1"
+	"go.temporal.io/api/serviceerror"
 	"go.temporal.io/sdk/client"
 	"go.temporal.io/sdk/temporalnexus"
 	"go.temporal.io/sdk/workflow"
@@ -270,6 +272,213 @@ func (s *SharedServerSuite) TestNexusOperationTerminate() {
 	s.Contains(res.Stdout.String(), "Nexus Operation terminated")
 }
 
+func (s *SharedServerSuite) TestNexusOperationDelete() {
+	endpointName, w := s.setupNexusEndpointAndWorker(s.T())
+	defer w.Stop()
+
+	opID := "delete-op-" + uuid.NewString()[:8]
+	res := s.Execute(
+		"nexus", "operation", "start",
+		"--address", s.Address(),
+		"--endpoint", endpointName,
+		"--service", "test-service",
+		"--operation", "test-op",
+		"--operation-id", opID,
+		"--input", `"hello"`,
+	)
+	s.NoError(res.Err)
+
+	s.Eventually(func() bool {
+		res = s.Execute(
+			"nexus", "operation", "describe",
+			"--address", s.Address(),
+			"--operation-id", opID,
+		)
+		return res.Err == nil
+	}, 30*time.Second, 500*time.Millisecond)
+
+	res = s.Execute(
+		"nexus", "operation", "delete",
+		"--address", s.Address(),
+		"--operation-id", opID,
+	)
+	s.EqualError(res.Err, "user denied confirmation")
+	s.Contains(res.Stdout.String(), opID)
+
+	res = s.Execute(
+		"nexus", "operation", "delete",
+		"--address", s.Address(),
+		"--operation-id", opID,
+		"--yes",
+	)
+	s.NoError(res.Err)
+	s.Contains(res.Stdout.String(), "Nexus Operation deletion requested")
+
+	s.Eventually(func() bool {
+		res = s.Execute(
+			"nexus", "operation", "describe",
+			"--address", s.Address(),
+			"--operation-id", opID,
+		)
+		return isNotFoundErr(res.Err)
+	}, 30*time.Second, 500*time.Millisecond)
+}
+
+func (s *SharedServerSuite) TestNexusOperationDelete_WithoutRunIDDeletesLatestRun() {
+	endpointName, w := s.setupNexusEndpointAndWorker(s.T())
+	defer w.Stop()
+
+	opID := "delete-latest-op-" + uuid.NewString()[:8]
+	startOperation := func(extraArgs ...string) string {
+		args := []string{
+			"nexus", "operation", "start",
+			"--address", s.Address(),
+			"--endpoint", endpointName,
+			"--service", "test-service",
+			"--operation", "test-op",
+			"--operation-id", opID,
+			"--input", `"hello"`,
+			"--output", "json",
+		}
+		res := s.Execute(append(args, extraArgs...)...)
+		s.NoError(res.Err)
+		var started struct {
+			RunId string `json:"runId"`
+		}
+		s.NoError(json.Unmarshal(res.Stdout.Bytes(), &started))
+		s.NotEmpty(started.RunId)
+		return started.RunId
+	}
+
+	firstRunID := startOperation()
+
+	// Wait for the first run to close so the same Operation ID can be reused.
+	res := s.Execute(
+		"nexus", "operation", "result",
+		"--address", s.Address(),
+		"--operation-id", opID,
+		"--run-id", firstRunID,
+		"--output", "json",
+	)
+	s.NoError(res.Err)
+
+	latestRunID := startOperation("--id-reuse-policy", "AllowDuplicate")
+	s.NotEqual(firstRunID, latestRunID)
+
+	s.Eventually(func() bool {
+		res = s.Execute(
+			"nexus", "operation", "describe",
+			"--address", s.Address(),
+			"--operation-id", opID,
+			"--run-id", latestRunID,
+		)
+		return res.Err == nil
+	}, 30*time.Second, 500*time.Millisecond)
+
+	res = s.Execute(
+		"nexus", "operation", "delete",
+		"--address", s.Address(),
+		"--operation-id", opID,
+		"--yes",
+	)
+	s.NoError(res.Err)
+	s.Contains(res.Stdout.String(), "Nexus Operation deletion requested")
+
+	// Omitting --run-id deletes the latest run, leaving the earlier run intact.
+	s.Eventually(func() bool {
+		res = s.Execute(
+			"nexus", "operation", "describe",
+			"--address", s.Address(),
+			"--operation-id", opID,
+			"--run-id", latestRunID,
+		)
+		return isNotFoundErr(res.Err)
+	}, 30*time.Second, 500*time.Millisecond)
+	s.Eventually(func() bool {
+		res = s.Execute(
+			"nexus", "operation", "describe",
+			"--address", s.Address(),
+			"--operation-id", opID,
+			"--run-id", firstRunID,
+		)
+		return res.Err == nil
+	}, 30*time.Second, 500*time.Millisecond)
+}
+
+func (s *SharedServerSuite) TestNexusOperationDelete_RunID_JSON() {
+	endpointName, w := s.setupNexusEndpointAndWorker(s.T())
+	defer w.Stop()
+
+	opID := "delete-run-op-" + uuid.NewString()[:8]
+	res := s.Execute(
+		"nexus", "operation", "start",
+		"--address", s.Address(),
+		"--endpoint", endpointName,
+		"--service", "test-service",
+		"--operation", "test-op",
+		"--operation-id", opID,
+		"--input", `"hello"`,
+		"--output", "json",
+	)
+	s.NoError(res.Err)
+	var started struct {
+		RunId string `json:"runId"`
+	}
+	s.NoError(json.Unmarshal(res.Stdout.Bytes(), &started))
+	s.NotEmpty(started.RunId)
+
+	s.Eventually(func() bool {
+		res = s.Execute(
+			"nexus", "operation", "describe",
+			"--address", s.Address(),
+			"--operation-id", opID,
+			"--run-id", started.RunId,
+		)
+		return res.Err == nil
+	}, 30*time.Second, 500*time.Millisecond)
+
+	res = s.Execute(
+		"nexus", "operation", "delete",
+		"--address", s.Address(),
+		"--operation-id", opID,
+		"--run-id", started.RunId,
+		"--yes",
+		"--output", "json",
+	)
+	s.NoError(res.Err)
+	var deleted struct {
+		OperationId string `json:"operationId"`
+		RunId       string `json:"runId"`
+		Status      string `json:"status"`
+	}
+	s.NoError(json.Unmarshal(res.Stdout.Bytes(), &deleted))
+	s.Equal(opID, deleted.OperationId)
+	s.Equal(started.RunId, deleted.RunId)
+	s.Equal("DELETE_REQUESTED", deleted.Status)
+
+	s.Eventually(func() bool {
+		res = s.Execute(
+			"nexus", "operation", "describe",
+			"--address", s.Address(),
+			"--operation-id", opID,
+			"--run-id", started.RunId,
+		)
+		return isNotFoundErr(res.Err)
+	}, 30*time.Second, 500*time.Millisecond)
+}
+
+func (s *SharedServerSuite) TestNexusOperationDelete_MissingOperationID() {
+	res := s.Execute("nexus", "operation", "delete", "--address", s.Address(), "--yes")
+	s.ErrorContains(res.Err, "operation-id")
+}
+
+// isNotFoundErr reports whether err is the server's NotFound, so deletion waits
+// don't treat a transient RPC failure as proof the execution is gone.
+func isNotFoundErr(err error) bool {
+	var notFound *serviceerror.NotFound
+	return errors.As(err, &notFound)
+}
+
 func (s *SharedServerSuite) TestNexusOperationList() {
 	endpointName, w := s.setupNexusEndpointAndWorker(s.T())
 	defer w.Stop()
@@ -793,4 +1002,3 @@ func (s *SharedServerSuite) TestNexusOperationStart_InvalidSearchAttribute() {
 	s.Error(res.Err)
 	s.ErrorContains(res.Err, "invalid search attribute")
 }
-
diff --git a/internal/temporalcli/commands.yaml b/internal/temporalcli/commands.yaml
index 3a94ce74b..fd74ba530 100644
--- a/internal/temporalcli/commands.yaml
+++ b/internal/temporalcli/commands.yaml
@@ -2200,6 +2200,7 @@ commands:
         - nexus operation describe
         - nexus operation cancel
         - nexus operation terminate
+        - nexus operation delete
         - nexus operation list
         - nexus operation count
         - cli reference
@@ -2314,6 +2315,29 @@ commands:
           Reason for termination.
           Defaults to a message with the current user's name.
 
+  - name: temporal nexus operation delete
+    summary: Remove a Nexus Operation Execution (Experimental)
+    description: |
+      Delete a Nexus Operation Execution and its history. The request runs
+      asynchronously. If the Operation is running, the Service terminates it
+      before deletion. Without a Run ID, the latest run is deleted.
+
+      ```
+      temporal nexus operation delete \
+          --operation-id YourOperationId \
+          --yes
+      ```
+
+      Use "--run-id" to delete a specific run. Confirmation is required unless
+      "--yes" is passed.
+    option-sets:
+      - nexus-operation-reference
+    options:
+      - name: yes
+        type: bool
+        short: y
+        description: Don't prompt to confirm deletion.
+
   - name: temporal nexus operation list
     summary: List Nexus Operations matching a query (Experimental)
     description: |
diff --git a/internal/temporalcli/commands_test.go b/internal/temporalcli/commands_test.go
index 6b621ef18..af9ef6ebc 100644
--- a/internal/temporalcli/commands_test.go
+++ b/internal/temporalcli/commands_test.go
@@ -406,6 +406,7 @@ func StartDevServer(t *testing.T, options DevServerOptions) *DevServer {
 		d.Options.DynamicConfigValues = map[string]any{}
 	}
 	d.Options.DynamicConfigValues["system.forceSearchAttributesCacheRefreshOnRead"] = true
+	d.Options.DynamicConfigValues["system.forceNexusEndpointRefreshOnRead"] = true
 	d.Options.DynamicConfigValues["frontend.workerVersioningRuleAPIs"] = true
 	d.Options.DynamicConfigValues["frontend.workerVersioningDataAPIs"] = true
 	d.Options.DynamicConfigValues["frontend.workerVersioningWorkflowAPIs"] = true