diff --git a/src/Options.tsx b/src/Options.tsx
index aa570dc0..3f9c1efd 100644
--- a/src/Options.tsx
+++ b/src/Options.tsx
@@ -1,5 +1,6 @@
 import { KeyCode } from '@rc-component/util';
 import React from 'react';
+import isEnterOrSpaceKey from './isEnterOrSpaceKey';
 import type { PaginationLocale } from './interface';
 
 export type SizeChangerRender = (info: {
@@ -91,6 +92,17 @@ const Options: React.FC<OptionsProps> = (props) => {
     }
   };
 
+  const preventInnerKeyDown = (e: React.KeyboardEvent<HTMLSpanElement>) => {
+    if (disabled && isEnterOrSpaceKey(e)) {
+      e.preventDefault();
+    }
+  };
+
+  const unfocusableWhenDisabled = (node: React.ReactNode) =>
+    disabled && React.isValidElement<React.HTMLAttributes<HTMLElement>>(node)
+      ? React.cloneElement(node, { tabIndex: -1 })
+      : node;
+
   const getPageSizeOptions = () => {
     if (
       pageSizeOptions.some(
@@ -150,8 +162,8 @@ const Options: React.FC<OptionsProps> = (props) => {
             {locale.jump_to_confirm}
           </button>
         ) : (
-          <span onClick={go} onKeyUp={go}>
-            {goButton}
+          <span onClick={go} onKeyUp={go} onKeyDown={preventInnerKeyDown}>
+            {unfocusableWhenDisabled(goButton)}
           </span>
         );
     }
diff --git a/src/Pager.tsx b/src/Pager.tsx
index 5a512afd..3e2d09a5 100644
--- a/src/Pager.tsx
+++ b/src/Pager.tsx
@@ -11,6 +11,7 @@ export interface PagerProps extends Pick<PaginationProps, 'itemRender'> {
   className?: string;
   style?: React.CSSProperties;
   showTitle: boolean;
+  disabled?: boolean;
   onClick?: (page: number) => void;
   onKeyPress?: (
     e: React.KeyboardEvent<HTMLLIElement>,
@@ -28,6 +29,7 @@ const Pager: React.FC<PagerProps> = (props) => {
     className,
     style,
     showTitle,
+    disabled,
     onClick,
     onKeyPress,
     itemRender,
@@ -59,21 +61,26 @@ const Pager: React.FC<PagerProps> = (props) => {
       {page}
     </a>,
   );
+  const pagerContent =
+    disabled && React.isValidElement<React.HTMLAttributes<HTMLElement>>(pager)
+      ? React.cloneElement(pager, { tabIndex: -1 })
+      : pager;
   const pagerLabel = `${pageLabel} ${page}`.trim();
 
-  return pager ? (
+  return pagerContent ? (
     <li
       title={showTitle ? String(page) : null}
       className={cls}
       style={style}
       onClick={handleClick}
       onKeyDown={handleKeyPress}
-      tabIndex={0}
+      tabIndex={disabled ? null : 0}
       role="button"
       aria-label={pagerLabel}
       aria-current={active ? 'page' : undefined}
+      aria-disabled={disabled || undefined}
     >
-      {pager}
+      {pagerContent}
     </li>
   ) : null;
 };
diff --git a/src/Pagination.tsx b/src/Pagination.tsx
index 2ca06bd8..5a98a205 100644
--- a/src/Pagination.tsx
+++ b/src/Pagination.tsx
@@ -296,7 +296,7 @@ const Pagination: React.FC<PaginationProps> = (props) => {
       ),
     );
     return React.isValidElement<HTMLButtonElement>(prevButton)
-      ? React.cloneElement(prevButton, { disabled: !hasPrev })
+      ? React.cloneElement(prevButton, { disabled: !hasPrev || disabled })
       : prevButton;
   }
 
@@ -312,7 +312,7 @@ const Pagination: React.FC<PaginationProps> = (props) => {
       ),
     );
     return React.isValidElement<HTMLButtonElement>(nextButton)
-      ? React.cloneElement(nextButton, { disabled: !hasNext })
+      ? React.cloneElement(nextButton, { disabled: !hasNext || disabled })
       : nextButton;
   }
 
@@ -322,6 +322,28 @@ const Pagination: React.FC<PaginationProps> = (props) => {
     }
   }
 
+  function preventInnerDefault(event: React.MouseEvent<HTMLUListElement>) {
+    if (disabled) {
+      event.preventDefault();
+    }
+  }
+
+  function preventInnerKeyDown(event: React.KeyboardEvent<HTMLElement>) {
+    if (disabled && isEnterOrSpaceKey(event)) {
+      event.preventDefault();
+    }
+  }
+
+  function withUnfocusable(node: React.ReactNode) {
+    if (
+      disabled &&
+      React.isValidElement<React.HTMLAttributes<HTMLElement>>(node)
+    ) {
+      return React.cloneElement(node, { tabIndex: -1 });
+    }
+    return node;
+  }
+
   let jumpPrev: React.ReactElement<PagerProps> = null;
 
   const dataOrAriaAttributeProps = pickAttrs(props, {
@@ -360,6 +382,7 @@ const Pagination: React.FC<PaginationProps> = (props) => {
     page: -1,
     className: paginationClassNames?.item,
     style: styles?.item,
+    disabled,
   };
 
   const prevPage = current - 1 > 0 ? current - 1 : 0;
@@ -377,14 +400,23 @@ const Pagination: React.FC<PaginationProps> = (props) => {
     if (goButton) {
       if (typeof goButton === 'boolean') {
         gotoButton = (
-          <button type="button" onClick={handleGoTO} onKeyUp={handleGoTO}>
+          <button
+            type="button"
+            onClick={handleGoTO}
+            onKeyUp={handleGoTO}
+            disabled={disabled}
+          >
             {locale.jump_to_confirm}
           </button>
         );
       } else {
         gotoButton = (
-          <span onClick={handleGoTO} onKeyUp={handleGoTO}>
-            {goButton}
+          <span
+            onClick={handleGoTO}
+            onKeyUp={handleGoTO}
+            onKeyDown={preventInnerKeyDown}
+          >
+            {withUnfocusable(goButton)}
           </span>
         );
       }
@@ -476,7 +508,7 @@ const Pagination: React.FC<PaginationProps> = (props) => {
         <li
           key="prev"
           onClick={jumpPrevHandle}
-          tabIndex={0}
+          tabIndex={disabled ? null : 0}
           onKeyDown={runIfEnterJumpPrev}
           className={clsx(`${prefixCls}-jump-prev`, {
             [`${prefixCls}-jump-prev-custom-icon`]:
@@ -484,8 +516,9 @@ const Pagination: React.FC<PaginationProps> = (props) => {
           })}
           role="button"
           aria-label={prevItemTitle}
+          aria-disabled={disabled || undefined}
         >
-          {jumpPrevContent}
+          {withUnfocusable(jumpPrevContent)}
         </li>
       ) : null;
 
@@ -493,7 +526,7 @@ const Pagination: React.FC<PaginationProps> = (props) => {
         <li
           key="next"
           onClick={jumpNextHandle}
-          tabIndex={0}
+          tabIndex={disabled ? null : 0}
           onKeyDown={runIfEnterJumpNext}
           className={clsx(`${prefixCls}-jump-next`, {
             [`${prefixCls}-jump-next-custom-icon`]:
@@ -501,8 +534,9 @@ const Pagination: React.FC<PaginationProps> = (props) => {
           })}
           role="button"
           aria-label={nextItemTitle}
+          aria-disabled={disabled || undefined}
         >
-          {jumpNextContent}
+          {withUnfocusable(jumpNextContent)}
         </li>
       ) : null;
     }
@@ -570,7 +604,7 @@ const Pagination: React.FC<PaginationProps> = (props) => {
 
   let prev = renderPrev(prevPage);
   if (isReactRenderable(prev)) {
-    const prevDisabled = !hasPrev || !allPages;
+    const prevDisabled = !hasPrev || !allPages || !!disabled;
     prev = (
       <li
         onClick={prevHandle}
@@ -584,27 +618,19 @@ const Pagination: React.FC<PaginationProps> = (props) => {
         role="button"
         aria-label={locale.prev_page}
       >
-        {prev}
+        {withUnfocusable(prev)}
       </li>
     );
   }
 
   let next = renderNext(nextPage);
   if (isReactRenderable(next)) {
-    let nextDisabled: boolean, nextTabIndex: number | null;
-
-    if (simple) {
-      nextDisabled = !hasNext;
-      nextTabIndex = hasPrev ? 0 : null;
-    } else {
-      nextDisabled = !hasNext || !allPages;
-      nextTabIndex = nextDisabled ? null : 0;
-    }
+    const nextDisabled = !hasNext || !allPages || !!disabled;
 
     next = (
       <li
         onClick={nextHandle}
-        tabIndex={nextTabIndex}
+        tabIndex={nextDisabled ? null : 0}
         onKeyDown={runIfEnterNext}
         className={clsx(`${prefixCls}-next`, paginationClassNames?.item, {
           [`${prefixCls}-disabled`]: nextDisabled,
@@ -614,7 +640,7 @@ const Pagination: React.FC<PaginationProps> = (props) => {
         role="button"
         aria-label={locale.next_page}
       >
-        {next}
+        {withUnfocusable(next)}
       </li>
     );
   }
@@ -632,7 +658,9 @@ const Pagination: React.FC<PaginationProps> = (props) => {
       className={cls}
       style={style}
       ref={paginationRef}
+      onClick={preventInnerDefault}
       {...dataOrAriaAttributeProps}
+      aria-disabled={disabled || undefined}
     >
       {totalText}
       {prev}
diff --git a/tests/__snapshots__/demo.test.tsx.snap b/tests/__snapshots__/demo.test.tsx.snap
index 2b1ffd7e..11058e3c 100644
--- a/tests/__snapshots__/demo.test.tsx.snap
+++ b/tests/__snapshots__/demo.test.tsx.snap
@@ -2135,28 +2135,29 @@ exports[`Example jumper 1`] = `
     禁用
   </h3>
   <ul
+    aria-disabled="true"
     class="rc-pagination rc-pagination-disabled"
   >
     <li
-      aria-disabled="false"
+      aria-disabled="true"
       aria-label="上一页"
-      class="rc-pagination-prev"
+      class="rc-pagination-prev rc-pagination-disabled"
       role="button"
-      tabindex="0"
     >
       <button
         aria-hidden="true"
         class="rc-pagination-item-link"
+        disabled=""
         tabindex="-1"
         title="上一页"
         type="button"
       />
     </li>
     <li
+      aria-disabled="true"
       aria-label="页 1"
       class="rc-pagination-item rc-pagination-item-1"
       role="button"
-      tabindex="0"
       title="1"
     >
       <a
@@ -2168,10 +2169,10 @@ exports[`Example jumper 1`] = `
       </a>
     </li>
     <li
+      aria-disabled="true"
       aria-label="向前 5 页"
       class="rc-pagination-jump-prev"
       role="button"
-      tabindex="0"
     >
       <button
         aria-hidden="true"
@@ -2182,10 +2183,10 @@ exports[`Example jumper 1`] = `
       />
     </li>
     <li
+      aria-disabled="true"
       aria-label="页 4"
       class="rc-pagination-item rc-pagination-item-4 rc-pagination-item-after-jump-prev"
       role="button"
-      tabindex="0"
       title="4"
     >
       <a
@@ -2198,10 +2199,10 @@ exports[`Example jumper 1`] = `
     </li>
     <li
       aria-current="page"
+      aria-disabled="true"
       aria-label="页 5"
       class="rc-pagination-item rc-pagination-item-5 rc-pagination-item-active"
       role="button"
-      tabindex="0"
       title="5"
     >
       <a
@@ -2213,10 +2214,10 @@ exports[`Example jumper 1`] = `
       </a>
     </li>
     <li
+      aria-disabled="true"
       aria-label="页 6"
       class="rc-pagination-item rc-pagination-item-6 rc-pagination-item-before-jump-next"
       role="button"
-      tabindex="0"
       title="6"
     >
       <a
@@ -2228,10 +2229,10 @@ exports[`Example jumper 1`] = `
       </a>
     </li>
     <li
+      aria-disabled="true"
       aria-label="向后 5 页"
       class="rc-pagination-jump-next"
       role="button"
-      tabindex="0"
     >
       <button
         aria-hidden="true"
@@ -2242,10 +2243,10 @@ exports[`Example jumper 1`] = `
       />
     </li>
     <li
+      aria-disabled="true"
       aria-label="页 23"
       class="rc-pagination-item rc-pagination-item-23"
       role="button"
-      tabindex="0"
       title="23"
     >
       <a
@@ -2257,15 +2258,15 @@ exports[`Example jumper 1`] = `
       </a>
     </li>
     <li
-      aria-disabled="false"
+      aria-disabled="true"
       aria-label="下一页"
-      class="rc-pagination-next"
+      class="rc-pagination-next rc-pagination-disabled"
       role="button"
-      tabindex="0"
     >
       <button
         aria-hidden="true"
         class="rc-pagination-item-link"
+        disabled=""
         tabindex="-1"
         title="下一页"
         type="button"
@@ -2704,6 +2705,7 @@ exports[`Example jumperWithGoButton 1`] = `
       aria-label="下一页"
       class="rc-pagination-next"
       role="button"
+      tabindex="0"
     >
       <button
         aria-hidden="true"
@@ -4349,6 +4351,7 @@ exports[`Example simple 1`] = `
       aria-label="下一页"
       class="rc-pagination-next"
       role="button"
+      tabindex="0"
     >
       <button
         aria-hidden="true"
@@ -4395,6 +4398,7 @@ exports[`Example simple 1`] = `
       aria-label="下一页"
       class="rc-pagination-next"
       role="button"
+      tabindex="0"
     >
       <button
         aria-hidden="true"
@@ -4446,6 +4450,7 @@ exports[`Example simple 1`] = `
       aria-label="下一页"
       class="rc-pagination-next"
       role="button"
+      tabindex="0"
     >
       <button
         aria-hidden="true"
@@ -4502,6 +4507,7 @@ exports[`Example simple 1`] = `
       aria-label="下一页"
       class="rc-pagination-next"
       role="button"
+      tabindex="0"
     >
       <button
         aria-hidden="true"
@@ -4553,6 +4559,7 @@ exports[`Example simple 1`] = `
       aria-label="下一页"
       class="rc-pagination-next"
       role="button"
+      tabindex="0"
     >
       <button
         aria-hidden="true"
@@ -4636,6 +4643,7 @@ exports[`Example simple 1`] = `
       aria-label="下一页"
       class="rc-pagination-next"
       role="button"
+      tabindex="0"
     >
       <button
         aria-hidden="true"
diff --git a/tests/index.test.tsx b/tests/index.test.tsx
index 7cba57e2..d1acb310 100644
--- a/tests/index.test.tsx
+++ b/tests/index.test.tsx
@@ -1,5 +1,5 @@
 import type { RenderResult } from '@testing-library/react';
-import { render, fireEvent } from '@testing-library/react';
+import { createEvent, render, fireEvent } from '@testing-library/react';
 import React from 'react';
 import Pagination from '../src';
 import { resetWarned } from '@rc-component/util';
@@ -429,6 +429,108 @@ describe('Other props', () => {
     expect(
       container.querySelector('.rc-pagination-options-quick-jumper-button'),
     ).toBeDisabled();
+
+    // All pagination items should not be tabbable
+    expect(container.querySelector('ul')).toHaveAttribute(
+      'aria-disabled',
+      'true',
+    );
+    container.querySelectorAll('li[role="button"]').forEach((item) => {
+      expect(item).toHaveAttribute('aria-disabled', 'true');
+      expect(item).not.toHaveAttribute('tabindex');
+    });
+  });
+
+  it('disabled should override user passed aria-disabled', () => {
+    const { container } = render(
+      <Pagination total={30} disabled aria-disabled={false} />,
+    );
+    expect(container.querySelector('ul')).toHaveAttribute(
+      'aria-disabled',
+      'true',
+    );
+  });
+
+  it('should ignore user passed aria-disabled when not disabled', () => {
+    const { container } = render(<Pagination aria-disabled="true" />);
+    expect(container.querySelector('ul')).not.toHaveAttribute('aria-disabled');
+  });
+
+  it('should prevent default action of itemRender link when disabled', () => {
+    const itemRender = (page, type, element) =>
+      type === 'page' || type === 'prev' || type === 'next' ? (
+        <a href={`#${type}${page}`}>{page}</a>
+      ) : (
+        element
+      );
+    const { container } = render(
+      <Pagination
+        total={50}
+        defaultCurrent={2}
+        itemRender={itemRender}
+        disabled
+      />,
+    );
+    const link = container.querySelector('.rc-pagination-item-2 a');
+    const event = createEvent.click(link);
+    fireEvent(link, event);
+    expect(event.defaultPrevented).toBe(true);
+    expect(link).toHaveAttribute('tabindex', '-1');
+    expect(container.querySelector('.rc-pagination-prev a')).toHaveAttribute(
+      'tabindex',
+      '-1',
+    );
+    expect(container.querySelector('.rc-pagination-next a')).toHaveAttribute(
+      'tabindex',
+      '-1',
+    );
+  });
+
+  it('should not prevent default action of itemRender link when enabled', () => {
+    const itemRender = (page, type, element) =>
+      type === 'page' ? <a href={`#${page}`}>{page}</a> : element;
+    const { container } = render(
+      <Pagination total={50} defaultCurrent={2} itemRender={itemRender} />,
+    );
+    const link = container.querySelector('.rc-pagination-item-2 a');
+    const event = createEvent.click(link);
+    fireEvent(link, event);
+    expect(event.defaultPrevented).toBe(false);
+    expect(link).not.toHaveAttribute('tabindex');
+  });
+
+  it('should unfocus custom goButton and block activation keys when disabled', () => {
+    const goButton = <button type="button">Go</button>;
+    const { container } = render(
+      <Pagination total={50} showQuickJumper={{ goButton }} disabled />,
+    );
+    const button = container.querySelector(
+      '.rc-pagination-options-quick-jumper button',
+    );
+    expect(button).toHaveAttribute('tabindex', '-1');
+
+    const tabEvent = createEvent.keyDown(button, { key: 'Tab' });
+    fireEvent(button, tabEvent);
+    expect(tabEvent.defaultPrevented).toBe(false);
+
+    const enterEvent = createEvent.keyDown(button, { key: 'Enter' });
+    fireEvent(button, enterEvent);
+    expect(enterEvent.defaultPrevented).toBe(true);
+  });
+
+  it('should unfocus simple mode custom goButton when disabled', () => {
+    const goButton = <button type="button">Go</button>;
+    const { container } = render(
+      <Pagination total={50} simple showQuickJumper={{ goButton }} disabled />,
+    );
+    const button = container.querySelector(
+      '.rc-pagination-simple-pager button',
+    );
+    expect(button).toHaveAttribute('tabindex', '-1');
+
+    const enterEvent = createEvent.keyDown(button, { key: 'Enter' });
+    fireEvent(button, enterEvent);
+    expect(enterEvent.defaultPrevented).toBe(true);
   });
 });