diff --git a/py/src/braintrust/integrations/auto_test_scripts/test_auto_openai.py b/py/src/braintrust/integrations/auto_test_scripts/test_auto_openai.py
index 00cbf44e9..dfdfad1f2 100644
--- a/py/src/braintrust/integrations/auto_test_scripts/test_auto_openai.py
+++ b/py/src/braintrust/integrations/auto_test_scripts/test_auto_openai.py
@@ -3,6 +3,7 @@
 import inspect
 
 import openai
+from braintrust import wrap_openai
 from braintrust.auto import auto_instrument
 from braintrust.integrations.test_utils import autoinstrument_test_context
 from wrapt import FunctionWrapper
@@ -49,4 +50,20 @@ def _is_braintrust_wrapped(resource) -> bool:
     assert span["metadata"]["provider"] == "openai"
     assert "gpt-4o-mini" in span["metadata"]["model"]
 
+# 5. Manual wrapping after auto-instrumentation must not duplicate the span or tokens.
+with autoinstrument_test_context("test_openai_responses_metrics", integration="openai") as memory_logger:
+    client = wrap_openai(openai.OpenAI())
+    response = client.responses.create(
+        model="gpt-4o-mini",
+        input="What's 12 + 12?",
+        instructions="Just the number please",
+    )
+    assert response.output
+
+    spans = memory_logger.pop()
+    assert len(spans) == 1, f"Expected 1 Responses span, got {len(spans)}"
+    assert spans[0]["span_attributes"]["name"] == "openai.responses.create"
+    assert spans[0]["metrics"]["prompt_tokens"] == response.usage.input_tokens
+    assert spans[0]["metrics"]["completion_tokens"] == response.usage.output_tokens
+
 print("SUCCESS")
diff --git a/py/src/braintrust/integrations/openai/patchers.py b/py/src/braintrust/integrations/openai/patchers.py
index 532e97c60..0bc69fa4e 100644
--- a/py/src/braintrust/integrations/openai/patchers.py
+++ b/py/src/braintrust/integrations/openai/patchers.py
@@ -82,6 +82,8 @@ def _make_method_patchers(
             "name": wrap_name,
             "target_path": method,
             "wrapper": wrapper,
+            # The instance marker differs from the class-level setup markers.
+            "setup_patchers": (sync_patcher, async_patcher),
         },
     )
     return sync_patcher, async_patcher, instance_patcher
@@ -479,7 +481,7 @@ class methods. Only Braintrust's own patch marker should make
     ``wrap_openai()`` skip instance-level instrumentation.
     """
     cls_attr = inspect.getattr_static(type(resource), method_name, None)
-    return patcher.has_patch_marker(cls_attr)
+    return any(setup_patcher.has_patch_marker(cls_attr) for setup_patcher in patcher.setup_patchers)
 
 
 def _delegates_to_wrapped_method(resource: Any, method_name: str) -> bool: