diff --git a/.github/trigger_files/beam_PostCommit_Python_Dependency.json b/.github/trigger_files/beam_PostCommit_Python_Dependency.json
index 0c0e8ca6a12b..1aa32de42b22 100644
--- a/.github/trigger_files/beam_PostCommit_Python_Dependency.json
+++ b/.github/trigger_files/beam_PostCommit_Python_Dependency.json
@@ -1,4 +1,4 @@
 {
     "comment": "Modify this file in a trivial way to cause this test suite to run",
-    "modification": 8
+    "modification": 6
   }
diff --git a/sdks/python/pyproject.toml b/sdks/python/pyproject.toml
index 703047cb6ef1..9a00fe03ea07 100644
--- a/sdks/python/pyproject.toml
+++ b/sdks/python/pyproject.toml
@@ -31,7 +31,7 @@ requires = [
     # Avoid https://github.com/pypa/virtualenv/issues/2006
     "distlib==0.4.4",
     # Numpy headers
-    "numpy>=1.14.3,<2.5.0", # Update setup.py as well.
+    "numpy>=1.23.2,<2.6.0", # Update setup.py as well.
     # having cython here will create wheels that are platform dependent.
     "cython>=3.2.6,<4",
     ## deps for generating external transform wrappers:
diff --git a/sdks/python/setup.py b/sdks/python/setup.py
index 3279282fc6b9..621df4cf0cde 100644
--- a/sdks/python/setup.py
+++ b/sdks/python/setup.py
@@ -156,12 +156,11 @@ def cythonize(*args, **kwargs):
     'pyarrow>=14.0.1,<26.0.0',
   ]
 
-# Exclude pandas<=1.4.2 since it doesn't work with numpy 1.24.x.
-# Exclude 1.5.0 and 1.5.1 because of
-# https://github.com/pandas-dev/pandas/issues/45725
 # must update the below "docs" and "test" for extras_require
 dataframe_dependency = [
-    'pandas>=1.4.3,!=1.5.0,!=1.5.1,<2.4',
+    # pandas 2.2.2 is the first version that works with numpy 2.0.0+
+    # TODO(https://github.com/apache/beam/issues/40709): support pandas 3+
+    'pandas>=2.2.2,<2.4',
 ]
 
 milvus_dependency = ['pymilvus>=2.5.10,<3.0.0']
@@ -435,7 +434,9 @@ def get_portability_package_data():
           'jsonpickle>=3.0.4,<5.0.0',
           # numpy can have breaking changes in minor versions.
           # Use a strict upper bound.
-          'numpy>=1.14.3,<2.5.0',  # Update pyproject.toml as well.
+          # Increment the lower bound when the minimum Python version is
+          # updated.
+          'numpy>=1.23.2,<2.6.0',  # Update pyproject.toml as well.
           'objsize>=0.6.1,<0.8.0',
           'packaging>=22.0',
           'pillow>=12.1.1,<13',
@@ -490,7 +491,7 @@ def get_portability_package_data():
               'docstring-parser>=0.15,<1.0',
               'docutils>=0.18.1',
               'markdown',
-              'pandas<2.4.0',
+              'pandas<2.6.0',
               'openai',
               'virtualenv-clone>=0.5,<1.0',
           ],
@@ -501,7 +502,7 @@ def get_portability_package_data():
               'jinja2>=3.0,<3.2',
               'joblib>=1.0.1',
               'mock>=1.0.1,<6.0.0',
-              'pandas<2.4.0',
+              'pandas<2.6.0',
               'parameterized>=0.7.1,<0.10.0',
               'pydot>=1.2.0,<2',
               'pyhamcrest>=1.9,!=1.10.0,<3.0.0',
diff --git a/sdks/python/test-suites/tox/py311/build.gradle b/sdks/python/test-suites/tox/py311/build.gradle
index 3228469cd6bd..fe1202cc0d32 100644
--- a/sdks/python/test-suites/tox/py311/build.gradle
+++ b/sdks/python/test-suites/tox/py311/build.gradle
@@ -84,30 +84,15 @@ toxTask "testPy311pyarrow-25", "py311-pyarrow-25", "${posargs}"
 test.dependsOn "testPy311pyarrow-25"
 postCommitPyDep.dependsOn "testPy311pyarrow-25"
 
-// Create a test task for each supported minor version of pandas
-toxTask "testPy311pandas-14", "py311-pandas-14", "${posargs}"
-test.dependsOn "testPy311pandas-14"
-postCommitPyDep.dependsOn "testPy311pandas-14"
-
-toxTask "testPy311pandas-15", "py311-pandas-15", "${posargs}"
-test.dependsOn "testPy311pandas-15"
-postCommitPyDep.dependsOn "testPy311pandas-15"
-
-toxTask "testPy311pandas-20", "py311-pandas-20", "${posargs}"
-test.dependsOn "testPy311pandas-20"
-postCommitPyDep.dependsOn "testPy311pandas-20"
-
-// TODO(https://github.com/apache/beam/issues/31192): Add below suites
-// after dependency compat tests suite switches to Python 3.9 or we add
-// Python 2.2 support.
-
-// toxTask "testPy311pandas-21", "py311-pandas-21", "${posargs}"
-// test.dependsOn "testPy311pandas-21"
-// postCommitPyDep.dependsOn "testPy311pandas-21"
-
-// toxTask "testPy311pandas-22", "py311-pandas-22", "${posargs}"
-// test.dependsOn "testPy311pandas-22"
-// postCommitPyDep.dependsOn "testPy311pandas-22"
+// Create a test task for each supported minor version of pandas.
+// Keep in sync with [testenv:py311-pandas-...] in tox.ini.
+toxTask "testPy311pandas-22", "py311-pandas-22", "${posargs}"
+test.dependsOn "testPy311pandas-22"
+postCommitPyDep.dependsOn "testPy311pandas-22"
+
+toxTask "testPy311pandas-23", "py311-pandas-23", "${posargs}"
+test.dependsOn "testPy311pandas-23"
+postCommitPyDep.dependsOn "testPy311pandas-23"
 
 // TODO(https://github.com/apache/beam/issues/30908): Revise what are we testing
 
diff --git a/sdks/python/tox.ini b/sdks/python/tox.ini
index b579f91fd2eb..4d0b1903b130 100644
--- a/sdks/python/tox.ini
+++ b/sdks/python/tox.ini
@@ -365,16 +365,14 @@ commands =
   /bin/sh -c 'pytest -o junit_suite_name={envname} --junitxml=pytest_{envname}.xml -n 6 -m uses_pyarrow {posargs}; ret=$?; [ $ret = 5 ] && exit 0 || exit $ret'
 
 
-[testenv:py311-pandas-{14,15,20}]
+[testenv:py311-pandas-{22,23}]
+# Keep in line with dataframe_dependency in setup.py. pandas 2.2.2 is the first
+# release compatible with numpy 2.
 deps =
-  14: pandas>=1.4.3,<1.5.0
-  14: numpy>=1.14.3,<1.27.0
-  # Exclude 1.5.0 and 1.5.1 because of https://github.com/pandas-dev/pandas/issues/45725
-  15: pandas>=1.5.2,<1.6.0
-  15: numpy>=1.14.3,<1.27.0
-  20: pandas>=2.0.0,<2.1.0
-  20: pyarrow>=7
-  20: numpy>=1.14.3,<1.27.0
+  # Lower bound of the supported range; also keeps numpy 1.x covered.
+  22: pandas>=2.2.2,<2.3.0
+  22: numpy>=1.23.2,<2.0.0
+  23: pandas>=2.3.0,<2.4.0
 commands =
   # Log pandas and numpy version for debugging
   /bin/sh -c "pip freeze | grep -E '(pandas|numpy)'"