diff --git a/cardano_node_tests/tests/test_chain_transactions.py b/cardano_node_tests/tests/test_chain_transactions.py
index 04d1de3d2..637811951 100644
--- a/cardano_node_tests/tests/test_chain_transactions.py
+++ b/cardano_node_tests/tests/test_chain_transactions.py
@@ -74,11 +74,7 @@ def _repeat_submit(cluster_obj: clusterlib.ClusterLib, tx_file: pl.Path) -> str:
         try:
             cluster_obj.g_transaction.submit_tx_bare(tx_file=tx_file)
         except clusterlib.CLIError as exc:
-            exc_str = str(exc)
-            inputs_spent = (
-                "All inputs are spent" in exc_str  # In cardano-node >= 10.6.0
-                or "BadInputsUTxO" in exc_str
-            )
+            inputs_spent = helpers.is_inputs_spent_err(str(exc))
             if r == 0 and inputs_spent:
                 err_str = "Tx input is missing, maybe temporary fork happened?"
             elif inputs_spent:
diff --git a/cardano_node_tests/tests/test_tx_many_utxos.py b/cardano_node_tests/tests/test_tx_many_utxos.py
index 1d9c21267..5711d5ad4 100644
--- a/cardano_node_tests/tests/test_tx_many_utxos.py
+++ b/cardano_node_tests/tests/test_tx_many_utxos.py
@@ -96,7 +96,7 @@ def many_utxos(
                 less_than_1_ada = int(float(multiple / 20) * 1_000_000)
                 amount = less_than_1_ada + 1_000_000
 
-                # Repeat transaction when "BadInputsUTxO" error happens
+                # Repeat transaction when the Tx inputs were already spent
                 excp: clusterlib.CLIError | None = None
                 for r in range(2):
                     if r > 0:
@@ -110,16 +110,11 @@ def many_utxos(
                             amount=amount,
                         )
                     except clusterlib.CLIError as err:
-                        # The "BadInputsUTxO" error happens when a single UTxO is used in two
-                        # transactions. This can happen from time to time, we stress
+                        # The "inputs already spent" error happens when a single UTxO is used
+                        # in two transactions. This can happen from time to time, we stress
                         # the network here and waiting for 2 blocks may not be enough to get a
                         # transaction through.
-                        exc_str = str(err)
-                        inputs_spent = (
-                            "All inputs are spent" in exc_str  # In cardano-node >= 10.6.0
-                            or "BadInputsUTxO" in exc_str
-                        )
-                        if not inputs_spent:
+                        if not helpers.is_inputs_spent_err(str(err)):
                             raise
                         excp = err
                     else:
diff --git a/cardano_node_tests/tests/test_tx_mempool.py b/cardano_node_tests/tests/test_tx_mempool.py
index fda3f1ffe..bdcb5ddc1 100644
--- a/cardano_node_tests/tests/test_tx_mempool.py
+++ b/cardano_node_tests/tests/test_tx_mempool.py
@@ -97,11 +97,7 @@ def test_query_mempool_txin(
             try:
                 cluster.g_transaction.submit_tx_bare(tx_file=out_file_signed)
             except clusterlib.CLIError as exc:
-                exc_str = str(exc)
-                inputs_spent = (
-                    "All inputs are spent" in exc_str  # In cardano-node >= 10.6.0
-                    or "BadInputsUTxO" in exc_str
-                )
+                inputs_spent = helpers.is_inputs_spent_err(str(exc))
                 if r == 0 or not inputs_spent:
                     raise
                 break
diff --git a/cardano_node_tests/tests/test_tx_negative.py b/cardano_node_tests/tests/test_tx_negative.py
index 819c49142..79ea2d6da 100644
--- a/cardano_node_tests/tests/test_tx_negative.py
+++ b/cardano_node_tests/tests/test_tx_negative.py
@@ -773,8 +773,7 @@ def test_duplicated_tx(
         exc_value = str(excinfo.value)
         with common.allow_unstable_error_messages():
             assert (
-                "All inputs are spent" in exc_value  # In cardano-node >= 10.6.0
-                or "(ValueNotConservedUTxO" in exc_value
+                helpers.is_inputs_spent_err(exc_value) or "(ValueNotConservedUTxO" in exc_value
             ), exc_value
 
     @allure.link(helpers.get_vcs_link())
@@ -1310,7 +1309,7 @@ def test_nonexistent_utxo_ix(
         * Get valid UTxO from payment address
         * Modify UTxO index to nonexistent value (5)
         * Attempt to build or submit transaction using invalid UTxO index
-        * Check that transaction fails with empty UTxO or BadInputsUTxO error
+        * Check that transaction fails with empty UTxO or inputs already spent error
         """
         temp_template = common.get_test_id(cluster)
 
@@ -1336,10 +1335,7 @@ def test_nonexistent_utxo_ix(
                 ), err_str
         elif build_method == clusterlib_utils.BuildMethods.BUILD_RAW:
             with common.allow_unstable_error_messages():
-                assert (
-                    "All inputs are spent" in err_str  # In cardano-node >= 10.6.0
-                    or "BadInputsUTxO" in err_str
-                ), err_str
+                assert helpers.is_inputs_spent_err(err_str), err_str
         else:
             msg = f"Unsupported build method: {build_method}"
             raise ValueError(msg)
@@ -1363,7 +1359,7 @@ def test_nonexistent_utxo_hash(
         * Get valid UTxO from payment address
         * Modify last 4 characters of UTxO hash to create nonexistent hash
         * Attempt to build or submit transaction using invalid UTxO hash
-        * Check that transaction fails with empty UTxO or BadInputsUTxO error
+        * Check that transaction fails with empty UTxO or inputs already spent error
         """
         temp_template = common.get_test_id(cluster)
 
@@ -1390,10 +1386,7 @@ def test_nonexistent_utxo_hash(
                 ), err_str
         elif build_method == clusterlib_utils.BuildMethods.BUILD_RAW:
             with common.allow_unstable_error_messages():
-                assert (
-                    "All inputs are spent" in err_str  # In cardano-node >= 10.6.0
-                    or "BadInputsUTxO" in err_str
-                ), err_str
+                assert helpers.is_inputs_spent_err(err_str), err_str
         else:
             msg = f"Unsupported build method: {build_method}"
             raise ValueError(msg)
diff --git a/cardano_node_tests/tests/tests_plutus/spend_build.py b/cardano_node_tests/tests/tests_plutus/spend_build.py
index efec1134e..25306589f 100644
--- a/cardano_node_tests/tests/tests_plutus/spend_build.py
+++ b/cardano_node_tests/tests/tests_plutus/spend_build.py
@@ -8,6 +8,7 @@
 from cardano_node_tests.tests import plutus_common
 from cardano_node_tests.utils import clusterlib_utils
 from cardano_node_tests.utils import dbsync_utils
+from cardano_node_tests.utils import helpers
 from cardano_node_tests.utils import tx_view
 from cardano_node_tests.utils.versions import VERSIONS
 
@@ -302,11 +303,7 @@ def _build_spend_locked_txin(  # noqa: C901
             ):
                 issues.ledger_4198.finish_test()
             # Check if resubmitting failed because an input UTxO was already spent
-            inputs_spent = (
-                "All inputs are spent" in str_exc  # In cardano-node >= 10.6.0
-                or "BadInputsUTxO" in str_exc
-            )
-            if not inputs_spent:
+            if not helpers.is_inputs_spent_err(str_exc):
                 raise
         else:
             pytest.fail("Transaction was not submitted successfully")
diff --git a/cardano_node_tests/tests/tests_plutus/spend_raw.py b/cardano_node_tests/tests/tests_plutus/spend_raw.py
index 89a99c017..8b3799e93 100644
--- a/cardano_node_tests/tests/tests_plutus/spend_raw.py
+++ b/cardano_node_tests/tests/tests_plutus/spend_raw.py
@@ -8,6 +8,7 @@
 from cardano_node_tests.tests import plutus_common
 from cardano_node_tests.utils import clusterlib_utils
 from cardano_node_tests.utils import dbsync_utils
+from cardano_node_tests.utils import helpers
 from cardano_node_tests.utils import tx_view
 from cardano_node_tests.utils.versions import VERSIONS
 
@@ -297,12 +298,7 @@ def _spend_locked_txin(  # noqa: C901
             cluster_obj.g_transaction.submit_tx_bare(tx_file=tx_signed)
         except clusterlib.CLIError as exc:
             # Check if resubmitting failed because an input UTxO was already spent
-            str_exc = str(exc)
-            inputs_spent = (
-                "All inputs are spent" in str_exc  # In cardano-node >= 10.6.0
-                or "BadInputsUTxO" in str_exc
-            )
-            if not inputs_spent:
+            if not helpers.is_inputs_spent_err(str(exc)):
                 raise
         else:
             pytest.fail("Transaction was not submitted successfully")
diff --git a/cardano_node_tests/tests/tests_plutus_v2/test_spend_collateral_build.py b/cardano_node_tests/tests/tests_plutus_v2/test_spend_collateral_build.py
index aa4b829ac..bffcc3306 100644
--- a/cardano_node_tests/tests/tests_plutus_v2/test_spend_collateral_build.py
+++ b/cardano_node_tests/tests/tests_plutus_v2/test_spend_collateral_build.py
@@ -210,11 +210,7 @@ def test_with_total_return_collateral(
             ):
                 issues.ledger_4198.finish_test()
             # Check if resubmitting failed because an input UTxO was already spent
-            inputs_spent = (
-                "All inputs are spent" in str_exc  # In cardano-node >= 10.6.0
-                or "BadInputsUTxO" in str_exc
-            )
-            if not inputs_spent:
+            if not helpers.is_inputs_spent_err(str_exc):
                 raise
         else:
             pytest.fail("Transaction was not submitted successfully")
@@ -361,11 +357,7 @@ def test_collateral_with_tokens(
             ):
                 issues.ledger_4198.finish_test()
             # Check if resubmitting failed because an input UTxO was already spent
-            inputs_spent = (
-                "All inputs are spent" in str_exc  # In cardano-node >= 10.6.0
-                or "BadInputsUTxO" in str_exc
-            )
-            if not inputs_spent:
+            if not helpers.is_inputs_spent_err(str_exc):
                 raise
         else:
             pytest.fail("Transaction was not submitted successfully")
diff --git a/cardano_node_tests/tests/tests_plutus_v2/test_spend_collateral_raw.py b/cardano_node_tests/tests/tests_plutus_v2/test_spend_collateral_raw.py
index fe57e540e..ab10cf422 100644
--- a/cardano_node_tests/tests/tests_plutus_v2/test_spend_collateral_raw.py
+++ b/cardano_node_tests/tests/tests_plutus_v2/test_spend_collateral_raw.py
@@ -171,11 +171,7 @@ def test_with_total_return_collateral(
             ):
                 issues.ledger_4198.finish_test()
             # Check if resubmitting failed because an input UTxO was already spent
-            inputs_spent = (
-                "All inputs are spent" in str_exc  # In cardano-node >= 10.6.0
-                or "BadInputsUTxO" in str_exc
-            )
-            if not inputs_spent:
+            if not helpers.is_inputs_spent_err(str_exc):
                 raise
         else:
             pytest.fail("Transaction was not submitted successfully")
@@ -336,11 +332,7 @@ def test_collateral_with_tokens(
             ):
                 issues.ledger_4198.finish_test()
             # Check if resubmitting failed because an input UTxO was already spent
-            inputs_spent = (
-                "All inputs are spent" in str_exc  # In cardano-node >= 10.6.0
-                or "BadInputsUTxO" in str_exc
-            )
-            if not inputs_spent:
+            if not helpers.is_inputs_spent_err(str_exc):
                 raise
         else:
             pytest.fail("Transaction was not submitted successfully")
diff --git a/cardano_node_tests/utils/helpers.py b/cardano_node_tests/utils/helpers.py
index 98b683956..adc624a36 100644
--- a/cardano_node_tests/utils/helpers.py
+++ b/cardano_node_tests/utils/helpers.py
@@ -342,6 +342,26 @@ def is_in_interval(num1: float, num2: float, *, frac: float = 0.1) -> bool:
     return _min <= num1 <= _max
 
 
+def is_inputs_spent_err(err_str: str) -> bool:
+    """Check if the error message indicates that the Tx inputs were already spent.
+
+    The ledger reports this condition with a different error in each era, so all the known
+    variants are accepted. In the Dijkstra era the Conway mempool failure is injected as the
+    dedicated `AllInputsAreSpent` failure.
+
+    Args:
+        err_str: An error message to check.
+
+    Returns:
+        bool: `True` if the error was caused by already spent Tx inputs.
+    """
+    return (
+        "All inputs are spent" in err_str  # Conway era, in cardano-node >= 10.6.0
+        or "AllInputsAreSpent" in err_str  # Dijkstra era
+        or "BadInputsUTxO" in err_str
+    )
+
+
 @functools.lru_cache(maxsize=100)
 def tool_has(command: str) -> bool:
     """Check if a tool has a subcommand or argument available.
diff --git a/cardano_node_tests/utils/submit_api.py b/cardano_node_tests/utils/submit_api.py
index 71b5936ed..9360987cc 100644
--- a/cardano_node_tests/utils/submit_api.py
+++ b/cardano_node_tests/utils/submit_api.py
@@ -14,6 +14,7 @@
 
 from cardano_node_tests.utils import cluster_nodes
 from cardano_node_tests.utils import custom_clusterlib
+from cardano_node_tests.utils import helpers
 from cardano_node_tests.utils import http_client
 
 LOGGER = logging.getLogger(__name__)
@@ -150,12 +151,7 @@ def submit_tx(
                 err = None
             except SubmitApiError as exc:
                 # Check if resubmitting failed because an input UTxO was already spent
-                exc_str = str(exc)
-                inputs_spent = (
-                    "All inputs are spent" in exc_str  # In cardano-node >= 10.6.0
-                    or "BadInputsUTxO" in exc_str
-                )
-                if not inputs_spent:
+                if not helpers.is_inputs_spent_err(str(exc)):
                     raise
                 err = exc
                 # If here, the TX is likely still in mempool and we need to wait
diff --git a/framework_tests/test_helpers.py b/framework_tests/test_helpers.py
index 23d032425..64771bb97 100644
--- a/framework_tests/test_helpers.py
+++ b/framework_tests/test_helpers.py
@@ -497,6 +497,34 @@ def test_custom_frac(self):
         assert helpers.is_in_interval(79, 100, frac=0.2) is False
 
 
+class TestIsInputsSpentErr:
+    """Tests for `is_inputs_spent_err`."""
+
+    @pytest.mark.parametrize(
+        "err_str",
+        (
+            'ConwayApplyTxError (ConwayMempoolFailure "All inputs are spent." :| [])',
+            "DijkstraApplyTxError (AllInputsAreSpent :| [])",
+            "ShelleyTxValidationError (UtxowFailure (UtxoFailure (BadInputsUTxO ...",
+        ),
+    )
+    def test_known_variants(self, err_str: str):
+        """Recognize the error variant of each era."""
+        assert helpers.is_inputs_spent_err(err_str) is True
+
+    @pytest.mark.parametrize(
+        "err_str",
+        (
+            "",
+            'ConwayApplyTxError (ConwayMempoolFailure "Insufficient collateral" :| [])',
+            "ValueNotConservedUTxO",
+        ),
+    )
+    def test_unrelated_errors(self, err_str: str):
+        """Don't match errors with an unrelated cause."""
+        assert helpers.is_inputs_spent_err(err_str) is False
+
+
 class TestToolHas:
     """Tests for `tool_has`.